3 mouse models of dicer dependent inactivation of mirna activity in the early limb mesenchyme and the growth plate

Báo cáo y học: "Mouse maps of gene expression in the brain" pot

Ngày tải lên : 14/08/2014, 07:21

... consistent, indicating that the pattern is due to the promoter elements of the gene of interest rather than the genomic insertion point The anatomical annotators of the GENSAT data have embraced the ... distributed through the Mutant Mouse Research Resource Centers [8,9] In addition, for some of the most interesting expression patterns, the project is developing lines where the BAC containing the gene ... recombinant strain of mouse that eliminates a gene’s expression only in the cells that express the Cre These lines will be a valuable resource for investigators looking to understand the role of individual...

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Long run effects of government policy in the growth model with creative destruction

Ngày tải lên : 10/11/2015, 11:07

... intermediate good to the final-good production and inversely measures the market power of the intermediate-good producer 16 In the original model of Howitt (1999), labor is used only in the intermediate-good ... through innovations The infinite living households maximize their utility according to their additive preference over time 3.1 Technologies 14 In Howitt (1999) model nt means the input to vertical innovations, ... time Investment subsidy affects the incentive of capital investment, K t , by changing the its cost And the lower is the cost, the higher the investment Both policies have growth effect because they...

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Mouse models of breast cancer metastasis: Anna Fantozzi and Gerhard Christofori pdf

Ngày tải lên : 22/03/2014, 17:20

... and invasion in the later stages by inducing EMT [8] The role of TGF-β in breast cancer metastasis is still under investigation One of its major functions, beside the induction of EMT, is inducing ... models of breast cancer metastasis are essential to understanding the role of several molecules in modulating key steps during malignant progression In vivo imaging Non-invasive in vivo imaging ... [44] Surprisingly, conditional knockout of TGF-βRII in the mammary epithelium of the MMTV-PyMT mouse resulted in increased metastasis formation [69] Together, these experiments in mouse models demonstrate...

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báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc

Ngày tải lên : 19/06/2014, 10:20

... engage the hind limbs in coordinated stepping Rather, these mice braced their hind paws onto the base of the sidewalls of the walking compartment (Figure 4, upper panel; Additional file 2), avoiding ... the motor program required for the two 3NP-treated mice that braced their hind limbs against the inside walls of the walking compartment while simultaneously maintaining coordinated gait of the ... attempting to walk at a speed of 34 cm/s, demonstrating coordinated gait of the forelimbs but gait failure of the hind limbs Compare this to the coordinated gait of the forelimbs and hind limbs in...

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báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer''''s disease" potx

Ngày tải lên : 19/06/2014, 22:20

... key in promoting and maintaining the inflammatory environment in the AD brain Furthermore, it is unclear which Aβ species (1–40, 1–42, soluble or insoluble) are most closely related to cytokine ... observed in the brains of these transgenic mice compared to their respective con- trols, indicating the absence of an anti-inflammatory response All of the cytokines that were increased in the TgAPPsw ... Griffin WS: In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis Neurobiol Aging 1996, 17:761-6 Mrak RE, Griffin...

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báo cáo hóa học: " Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD" pptx

Ngày tải lên : 19/06/2014, 22:20

... pro-inflammatory cytokines These findings underscore the complexity of the brain's cytokine environment and its role in modifying microglial responses to Aβ peptides Aβ, itself, may also influence the gene ... shutting down the production of pro-inflammatory cytokines and increasing the production of factors that participate in tissue repair and wound healing [6] Anti-inflammatory, Th-2 cytokines such ... Resistin family lar to those stages observed in chronic inflammatory diseases of the lung or liver, including the induction of alternative activation A shift to alternative activation in brain innate...

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Báo cáo khoa học: "Teratological effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): induction of cleft palate in the ddY and C57BL/6 mouse" pptx

Ngày tải lên : 07/08/2014, 14:23

... fuse each other, resulting in a wide gap between them (Figure 1, 2) Histologically, the cleft was lined by nasal epithelial cells, medial epithelial cells of two opposing prominences, and then connected ... relatively insensitive to the induction of cleft palate by TCDD, which is also assumed to be due to the low-affinity AhR of the strain [25] Therefore, in our study, the low sensitivity of ddY mice to the ... However, an increase in the number of fetuses dying at the late stage was noted when 40 µg/kg bw of TCDD was administered on GD 11.5 The teratological effect of TCDD was clear in the incidence...

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Báo cáo y học: "Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination" pot

Ngày tải lên : 09/08/2014, 13:22

... filaggrin, a protein expressed in stratified epithelium but not in joints [4,6] It is interesting that many of the citrullinated proteins identified in inflamed CIA joint tissue and EAE brain tissue ... targeted by the autoantibody responses in these models Figure Our findings extend the results of others who described antibody reactivity to CCP in CIA [14] and the induction of EAE with citrulline-substituted ... thereby contributes to the development of RA [13] Alterations in the citrullination of myelin proteins and autoimmune targeting of citrullinated myelin proteins have been observed in MS Myelin...

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Báo cáo y học: " Pharmacological characterisation of antiinflammatory compounds in acute and chronic mouse models of cigarette smoke-induced inflammation" ppt

Ngày tải lên : 12/08/2014, 11:22

... For instance, while steroids lack efficacy in both the preclinical models and the clinic, approaches aimed at neutralizing TNF-alpha work in the preclinical models, but not work in the clinic In ... would examine the same endpoints in the models as in the clinic Typically, early proof-of-concept studies for COPD anti-inflammatory strategies in man assess inflammatory cell numbers in biofluids ... align with their ability to block cell infiltrates Finally, investigating the molecular mechanisms responsible for the effects of these compounds in the models was beyond the scope of these studies...

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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc

Ngày tải lên : 21/02/2014, 03:20

... The introduction of mutation into one of the putative Etsbinding sequences suppressed the promoter activity In addition, the speciﬁc binding of a nuclear protein to the oligonucleotide containing ... assay (EMSA) using the Ets consensus site at )133 As the involvement of the Ets consensus binding site at )133 in the promoter activity of the mouse a3 integrin gene was suggested by the luciferase ... a3b1 integrin plays essential roles in multiple processes during embryogenesis The promoter should thus contain elements directing the expression of this integrin in the kidney, lung, and skin...

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Báo cáo khoa học: Identiﬁcation of multiple isoforms of the cAMP-dependent protein kinase catalytic subunit in the bivalve mollusc Mytilus galloprovincialis potx

Ngày tải lên : 07/03/2014, 06:20

... (only in C6) (d) There was one peak at 1059.5 Da observed only in the C1 and C4 spectra, whereas another peak at 1605.7 Da was found in the spectra of the remaining isoforms: C2, C3, C5 and C6 Interestingly, ... isoforms of the C-subunit In order to demonstrate the presence of different isoforms of the PKA C-subunit in mussels, the protein was partially purified from the PAM and the mantle tissues of the mollusc, ... respectively On the other hand, fraction 18, corresponding to the first absorbance peak, without protein kinase activity, contained an unidentified protein < 30 kDa, and fractions 21–23 also contained an...

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Reseach on building models of community - based tourism (the case of Giang Mo Village, Cao Phong district, Hoa Binh province

Ngày tải lên : 20/04/2014, 17:13

... eastern and southeastern, Ninh Binh and Thanh Hoa province at the southern and southwestern Hoa Binh is one of the northern mountainous provinces with many ethnic minorities making up a culture ... program in the Sin Chai within the framework “Reinforcing competence for sustainable tourism imitative” Criterion of model is aspiring to take part in tourism services in order to develop sustainable ... Lien Son line, km from Sa Pa town The population is mainly ethnic H’Mong living about 120 households migrating from China since the 17th century H’Mong in the Sin Chai still preserves many their...

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holmes, lumley, et al. low-dimensional models of coherent structures in turbulence

Ngày tải lên : 24/04/2014, 17:20

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Báo cáo khoa học: "The expression and cellular localization of phospholipase Disozymes in the developing mouse testis" pps

Ngày tải lên : 07/08/2014, 20:23

... sitset eht ni sllec gidyeL laititsretni ni nees saw gniniatsonummi DLP esnetnI selubut suorefinimes eht ni sllec detaitnereffidnu emos ni gniniatsonummi DLP kaew dewohs yrtsimehcotsihonummI sllec ... desaercnI giF htiw dezilausiv saw ytivitcaeronummI ydobitna DLP-itna deifirup-ytiniffa eht htiw tcaer ot dewolla dna deziniffaraped erew )kciht mµ 5( seussit deddebme-niffarap fo snoitceS yrtsimehcotsihonummI ... -lynofluslyhtemlynehp Mm ,ninitorpa lm/gµ 01 ,nitpepuel lm/gµ 01 ,lCaN Mm 051 ,SDS %1.0 ,etalohcyxoed %1 ,001-X notirT %1 ,)2.7 Hp( SEPEH Mm 02[ reffub yassa noitatipicerponummi ni dezinegomoh erew selpmas...

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Báo cáo y học: "Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease" ppsx

Ngày tải lên : 09/08/2014, 01:23

... recombinant interleukin-2 (rec Il-2; 50 U/ml) or lipopolysaccharide (LPS; µg/ml) The amount of the secreted interferon-γ in the supernatant was then tested in duplicate using the enzyme-linked ... protein 60 [62] Relevance of the findings The question of whether our findings are of any significance for the understanding of CIJD is justified and needs answering TLR ligands are found in the ... auto-specificities) can respond to these signals, migrate to the joint, breach endothelial barriers, infiltrate the inflamed foci and sustain inflammatory processes by secreting cytokines in response to direct...

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everyone is a customer a proven method for measuring the value of every relationship in the era of collaborati phần 3 docx

Ngày tải lên : 10/08/2014, 11:20

... competition in the business world will center on gaining and maintaining the orchestration role for a value chain or industry More money can be made in managing interactions than in performing actions.” ... business? Let’s look again at our example of home ownership When buying and occupying a new home, we think of our needs as finding the home, negotiating the deal, arranging the financing, obtaining ... that they are defined from the business’s perspective, not the customer’s Thus, we tend to think of business in a product or service orientation We think about the movie industry, the clothing industry,...

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Primary Care of Musculoskeletal Problems in the Outpatient Setting - part 3 pptx

Ngày tải lên : 10/08/2014, 15:20

... movement by bending at the waist, allowing the arm to fall toward the floor, and rotating it in a circle With time, the size of the circle is increased and the sling removed during the exercise ... differ depending on the degree of intervention 13.1 Examination The examination will differ depending on the phase of AC Initially the patient may be holding the involved arm to the side and ... by measuring how far up the back the hand can reach to scratch the back There usually is a little difference with the dominating arm lagging behind the other arm This tests the limit of internal...

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Care of Musculoskeletal Problems in the Outpatient Setting - part 3 docx

Ngày tải lên : 11/08/2014, 13:20

... movement by bending at the waist, allowing the arm to fall toward the floor, and rotating it in a circle With time, the size of the circle is increased and the sling removed during the exercise ... differ depending on the degree of intervention 13.1 Examination The examination will differ depending on the phase of AC Initially the patient may be holding the involved arm to the side and ... by measuring how far up the back the hand can reach to scratch the back There usually is a little difference with the dominating arm lagging behind the other arm This tests the limit of internal...

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Treatment of Osteoarthritic Change in the Hip - part 3 potx

Ngày tải lên : 11/08/2014, 17:20

... tilting angle Results The chief complaint was hip joint pain in 11 patients, pain from the hip joint to the knee in 3, pain from the hip joint to the thigh in 1, femoral pain in 1, and lower limb ... 1, and lower limb pain in The mechanism of injury was sports in patients, falling during running in 1, falling on the stairs in 1, long-distance walking in 1, and unknown in 3: most patients ... with the convexity of the anterior margin of the femoral head In Situ Pinning for SCFE 63 In type B, the anterior outline of the head and neck appears as a straight line and the anterior margin...

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Báo cáo y học: "Regional differences in prediction models of lung function in Germany" ppsx

Ngày tải lên : 12/08/2014, 11:21

... studies Nevertheless, there were differences between the three studies in terms of the other determinants In KORA environmental tobacco smoke (ETS) and the use of at least one drug influencing lung ... diabetes were linked with low FVC in the SHIP study, while this was true for ETS and the use of medication influencing lung function in the KORA study However, the effect of diabetes in the SHIP study ... high as in the other two studies Our data are in line previous findings describing an impairment of lung function in subjects that are extremely overweight [12,20,21] Cigarette smoking is the major...

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3 ﻿mouse models of dicer dependent inactivation of mirna activity in the early limb mesenchyme and the growth plate

3 mouse models of dicer dependent inactivation of mirna activity in the early limb mesenchyme and the growth plate